SAFB1 Antibody

• Catalog Number: orb1732804
• Category: Antibodies
• Description: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 2E8
• Tested applications: ICC, WB
• Reactivity: Human
• Isotype: Mouse IgG1
• Immunogen: Purified recombinant human SAFB1 protein fragments expressed in E.coli.
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000; ICC: 1/50-1/200
• Conjugation: Unconjugated
• MW: Calculated MW: 103 kDa; Observed MW: 130 kDa
• Entrez: 6294
• UniProt ID: Q15424
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: SAFB; HAP; HET; SAFB1; Scaffold attachment factor
• Note: For research use only
• Expiration Date: 12 months from date of receipt.