SAFB antibody

• Catalog Number: orb131814
• Category: Antibodies
• Description: Rabbit polyclonal to SAFB. Scaffold attachment factor B (SAFB) is a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). SAFB is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. SAFB is thought to serve as a molecular base to assemble a transcriptosome complex in the vicinity of actively transcribed genes. SAFB is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: C-terminal region of human SAFB
• Concentration: 100 μg/ml BSA
• Dilution range: WB:1:1000-1:3000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 103
• UniProt ID: Q15424
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti Scaffold attachment factor B1 antibody, anti
• Note: For research use only
• Application notes: WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; ; Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human SAFB.
• Expiration Date: 12 months from date of receipt.