Rubitecan

SKU: orb1220554

Description

Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.(In Vitro):Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 μM, respectively.

Key Properties

• CAS Number: 91421-42-0
• MW: 393.35
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₅N₃O₆
• SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc([N+]([O-])=O)c4cc3Cn1c2=O
• Target: Topoisomerase
• Solubility: DMSO:125 mg/mL (317.78 mM)

Bioactivity

• In Vitro:
  Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 μM, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RFS 2000 | 9-Nitrocamptothecin

Quick Database Links

Gene Symbol

Topoisomerase