RSV604

SKU: orb1299892

Description

RSV604

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 676128-63-5
• MW: 388.39
• Purity: 99.49%
• Formula: C₂₂H₁₇FN₄O₂
• SMILES: Fc1ccccc1NC(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O
• Target: RSV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.3 mM);DMSO:195 mg/mL (502.07 mM)

Bioactivity

• Target IC50:
  Nucleocapsid protein:1.6 μM (Kd)
• In Vivo:
  RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis an the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cell.
• In Vitro:
  RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculatio.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea, A60444, A-60444, A 60444, inhibit, nucleocapsid, Inhibitor, syncytial, RSV604, RSV-604, RSV, RSV 604, respiratory, Respiratory syncytial virus, protein, virus

Compound Identifiers

PubChem CID

5279172