RSV antibody

• Catalog Number: orb411595
• Category: Antibodies
• Description: Human monoclonal antibody to RSV
• Species/Host: Human
• Clonality: Monoclonal
• Clone Number: RSHZ19 (Felvizumab)
• Tested applications: ELISA
• Reactivity: Virus
• Isotype: IgG1
• Immunogen: This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: RSV
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: SB 209763; respiratory syncytial virus
• Note: For research use only
• Application notes: Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
• Expiration Date: 12 months from date of receipt.