Ribociclib

SKU: orb1300987

Description

Ribociclib

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1211441-98-3
• MW: 434.54
• Purity: 99.88%
• Formula: C₂₃H₃₀N₈O
• SMILES: C(N(C)C)(=O)C=1N(C=2C(C1)=CN=C(NC3=CC=C(C=N3)N4CCNCC4)N2)C5CCCC5
• Target: VEGFR,CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.51 mM);DMSO:9 mg/mL (20.71 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  4T1 cells:> 10 μM|CDK4:10 nM|HepG2 cells:> 10 μM|Jurkat cells:> 10 μM|HCC827 cells:> 10 μM|MCF-7 cells:> 10 μM|CCRF-CEM cells:> 10 μM|CDK6:39 nM|Hep 3B2 cells:> 10 μM|A375 cells:> 10 μM|HeLa cells:> 10 μM A549 cells:> 10 μM|B16 F10 cells:> 10 μM|BXPC-3 cells:68.37 μM|MDA-MB-231 cells:> 10 μM
• In Vivo:
  LEE011 inhibit the growth of neuroblastoma cells, a process regulated by G1 cell cycle arrest and cellular senescence. It demonstrates significant growth suppression in 12 out of 17 neuroblastoma types evaluated, with an average IC50 of 307 nM.
• In Vitro:
  LEE011 (200 mg/kg/day, p.o.) significantly delaye the growth of BE2C or 1643 cells in mice without causing weight loss or Other toxic symptoms.
• Cell Research:
  A panel of neuroblastoma cell lines, selected based upon prior demonstration of substratee adherent growth, is plated in triplicate o the Xcelligence Real-Time Cell Electronic Sensing system and treated 24 hours later with a four-log dose range of inhibitor or with a dimethyl sulfoxide (DMSO) control. Cell indexes are monitored continuously for ~100 hours, and IC50 Values are determined as follows: growth curves are generated by plottin the cell index as a function of time and are normalized to the cell index a the time of treatment for a baseline cell index of 1 the area unde the normalized growth curve fro the time of treatment to 96 hours posttreatment is then calculated using a baseline area of 1 (the cell index a the time of treatment). Areas are normalized to the DMSO control, an the resulting data are analyzed using a nonlinear log inhibitor versus normalized response function. All experiments are repeated at least once. (Only for Reference)

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK4, CDK, Cyclin dependent kinase, LEE011, LEE-011, LEE 011, Inhibitor, inhibit, Ribociclib, VEGFR4, VEGFR6

Compound Identifiers

PubChem CID

44631912