Rhesus macaque CTGF / CCN2 Protein

• Catalog Number: orb668877
• Category: Proteins
• Description: Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
• Reactivity: Monkey
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 37.3 kDa
• Target: CTGF
• Source: Rhesus macaque CTGF, His Tag (orb668877) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ala 349 (Accession # H9FQD5-1).
• Expression System: HEK293
• Biological Activity: Immobilized Rhesus macaque CTGF, His Tag at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CTGF Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).
• Expression Region: Gln 27 - Ala 349
• Endotoxins: 1.0 EU per μg
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: 5 mM HAC,100 mM NaCl, pH 5.5
• Alternative names: CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding p
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.3 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Immobilized Rhesus macaque CTGF, His Tag (Cat. No. orb668877) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CTGF Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).