RGFP966 (E-isomer)

SKU: orb1819329

Description

RGFP966 is a potent and highly selective HDAC3 inhibitor, demonstrating an IC50 of 0.08 μM and over 200-fold selectivity versus other HDAC isoforms. It is widely used in research to investigate epigenetic mechanisms in neurobiology, oncology, and metabolic diseases, with applications in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1396841-57-8
• MW: 362.4
• Purity: 99.93%
• Formula: C₂₁H₁₉FN₄O
• SMILES: Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CC=Cc2ccccc2)c1
• Target: HDAC
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.52 mM);DMSO:67 mg/mL (184.88 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HDAC3:0.08 μM
• In Vitro:
  In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RGFP 966, RGFP966, RGFP-966, E-isomer, HDAC3

Compound Identifiers

PubChem CID

68294528