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Catalog Number | orb1962197 |
---|---|
Category | Small Molecules |
Description | Resistin Protein, Human, Recombinant (His) |
Purity | 98.00% |
MW | 10—14 KDa, reducing conditions |
Biological Activity | Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM). Resistin has been shown to cause "high levels of 'bad' cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease, resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. Potentially links obesity to diabetes. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
≥90% as determined by SDS-PAGE | |
This protein contains the human RETN(Ser17-Pro108) was fused with the N-terminal His Tag and expressed in E. coli. |
≥90% as determined by SDS-PAGE | |
This protein contains the human RETN(Lys19-Pro108) was fused with the C-terminal His Tag and expressed in E. coli. |
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