Reserpine

SKU: orb1310288

Description

Reserpine is a VMAT2 inhibitor alkaloid derived from Rauwolfia serpentina, which depletes monoamine neurotransmitters. It is widely used in research to model depression and gastric ulcers in vivo, and to study catecholamine transport mechanisms in vitro within neuroscience and pharmacology.

Research Area

Neuroscience

Key Properties

• CAS Number: 50-55-5
• MW: 608.7
• Purity: >98%
• Formula: C₃₃H₄₀N₂O₉
• SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=C4C=CC(OC)=C5)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1
• Target: Monoamine transporter
• Solubility: Soluble in DMSO (35 mg/ml)

Bioactivity

• In Vivo:
  Reserpine was demonstrated to inhibit efflux pumps in 11, 21, and 48 out of the 102 unrelated clinical isolates tested, resulting in a fourfold decrease in the IC50 values and MICs of sparfloxacin, moxifloxacin, and ciprofloxacin, respectively.
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• In Vitro:
  Compared to the control group, alternate-day subcutaneous injections of reserpine solution (1 mg/kg s.c.) for three days significantly increased the duration of vacuous chewing, tongue protrusion, and facial twitching in rats. Reserpine reduced glutamate uptake in the cortical region of rats and caused a significant depletion of vasopressin/oxytocin - neurophysin-like immunoreactivity (LI) and CRH-L1 in the rat's median eminence. Additionally, reserpine notably restored performance in the delayed response task in monkeys. At a dose of 5 mg/kg, reserpine significantly increased pointless jaw movements in monkeys and reduced grooming behavior across all age groups in rats. A subcutaneous injection of 5 mg/kg reserpine in intact rats decreased extracellular dopamine levels to 4% of baseline values. The impact of reserpine on performance in a visual discrimination task, a reference memory task not reliant on the prefrontal cortex, was minimal.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC59272

Compound Identifiers

PubChem CID

5770