Quercitrin

SKU: orb1222119

Description

Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German camomile, endive, and kiwi, which makes quercitrin a potential biomarker for the consumption of these food products.

Key Properties

• CAS Number: 522-12-3
• MW: 448.39
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₀O₁₁
• SMILES: c1(c(c(=O)c2c(cc(cc2o1)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)c1cc(c(cc1)O)O
• Target: MAO
• Solubility: DMSO : ≥ 31 mg/mL; 69.14 mM

Bioactivity

• In Vivo:
  Animal model: Male ICR mice with carbon tetrachloride (CCl4) induced brain injury. Dosage: 50 and 100 mg/kg. Administration: Oral gavage; 50 and 100 mg/kg, once. Result: Dose-dependently decreased the levels of ROS and malondialdehyde (MDA) concentration in the hippocampus homogenates, and also dose-dependently decreased the CYP2E1 level in the brains. Increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Inhibited the N-methyl-D-aspartate receptor 2B subunit (NR2B) level and the activities of monoamine oxidase (MAO) and acetylcholine esterase (AChE) in mouse brains.
• In Vitro:
  Cell Proliferation Assay Cell line: DLD-1 colon cancer cell lines. Concentration: 5, 10, 25 and 50 μM. Incubation time: 24, 48 and 72 hours. Result: Time- and Dose-dependently decreased cell proliferation of colorectal carcinoma cells. Apoptosis Analysis Cell line: DLD-1 colon cancer cell lines. Concentration: 50 μM. Incubation time: 48 and 72 hours. Result: Induced cell apoptosis and time- and dose-dependently increased caspase-3 enzyme activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Quercitrin | Thujin

Quick Database Links

Gene Symbol

MAO