PSB-603

SKU: orb1704189

Description

PSB-603 is a potent and selective adenosine A2B receptor antagonist (Ki = 0.553 nM) with demonstrated anti-inflammatory properties. It is a valuable research tool for investigating the role of A2B signaling in inflammation, fibrosis, and cancer, applicable in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1092351-10-4
• MW: 529.01
• Purity: 97.14% (May vary between batches)
• Formula: C₂₄H₂₅ClN₆O₄S
• SMILES: CCCn1c(=O)[nH]c2[nH]c(nc2c1=O)-c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(Cl)cc1
• Target: Adenosine Receptor
• Solubility: DMSO:23.9 mg/mL (45.18 mM)

Bioactivity

• In Vivo:
  PSB-603 (5 mg/kg; i.p.) significantly reduces inflammation in local and systemic mice models of inflammation. In the inflamed paw, PSB-603 significantly decreases the levels of the inflammatory cytokines including IL-6, TNF-α and of ROS. PSB-603 reduces inflammation of the peritoneum by decreasing the infiltration of leukocytes.
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• In Vitro:
  In peripheral T cells, PSB-603 (100 nM) inhibits NECA-stimulated IL-6 release about 3-fold. PSB-603 (10 μM) shows no affinity for the human and rat A1 and A2A and human A3 receptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PSB603, PSB-603, PSB 603, Adenosine Receptor, AdenosineReceptor, A2B

Compound Identifiers

PubChem CID

44185871