PRT4165

SKU: orb1304528

Description

PRT4165 (NSC600157) is a small molecule inhibitor that potently and selectively blocks PRC1-mediated H2A ubiquitination. It is a valuable chemical probe for studying epigenetic regulation in cancer and stem cell biology, with utility in both in vitro biochemical assays and cellular research.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 31083-55-3
• MW: 235.24
• Purity: 98.91%
• Formula: C₁₅H₉NO₂
• SMILES: O=C1C(=Cc2cccnc2)C(=O)c2ccccc12
• Target: BMI-1,E1/E2/E3 Enzyme
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.5 mM);DMSO:11 mg/mL (46.76 mM)

Bioactivity

• Target IC50:
  RING1A-BMI1:3.9 μM
• In Vivo:
  Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo
• In Vitro:
  Inhibi the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex and H2A/H2AX ubiquitination

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

E3Enzyme, E3 ligating enzyme, E2Enzyme, E3 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E2 Enzyme, E2 conjugating enzyme, E1 Enzyme, E1 activating enzyme, BMI1, BMI-1, inhibit, NSC 600157, NSC600157, NSC-600157, Inhibitor, Ring1A, PRT 4165, PRT4165, PRT-4165, Ubiquitin activating enzyme, Ubiquitin ligase, Ubiquitin conjugating enzyme

Compound Identifiers

PubChem CID

207893