PRT-4165

SKU: orb1304528

Description

PRT4165 (NSC600157) is a small molecule inhibitor that potently and selectively blocks PRC1-mediated H2A ubiquitination. It is a valuable chemical probe for studying epigenetic regulation in cancer and stem cell biology, with utility in both in vitro biochemical assays and cellular research.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 31083-55-3
• MW: 235.24
• Purity: >98%
• Formula: C₁₅H₉NO₂
• SMILES: O=C1C(=Cc2cccnc2)C(=O)c2ccccc12
• Target: Ubiquitin ligase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml with warming).

Bioactivity

• Target IC50:
  RING1A-BMI1:3.9 μM
• In Vivo:
  Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo.
• In Vitro:
  Inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex and H2A/H2AX ubiquitination

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3Enzyme, E3 ligating enzyme, E2Enzyme, E3 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E2 Enzyme, E2 conjugating enzyme, E1 Enzyme, E1 activating enzyme, BMI1, BMI-1, inhibit, NSC 600157, NSC600157, NSC-600157, Inhibitor, Ring1A, PRT 4165, PRT4165, PRT-4165, Ubiquitin activating enzyme, Ubiquitin ligase, Ubiquitin conjugating enzyme

Compound Identifiers

PubChem CID

207893