PROTAC ER Degrader-14

SKU: orb2945534

Description

PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor/ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2504911-73-1
MW	743.865
Formula	C₄₄H₄₆FN₅O₅
SMILES	FC=1C=C([C@H]2[C@H](COC=3C2=CC=C(O)C3)C4=CC=CC=C4)C=CC1N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5
Target	Estrogen Receptor/ERR,PROTACs

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Estrogen Receptor/ERR,PROTACs

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