PROTAC CDK4/6 degrader 1

SKU: orb2646121

Description

Compound 7f (PROTAC CDK4/6 degrader 1) is a potent dual degrader of CDK4 (DC50=10.5 nM) and CDK6 (DC50=2.5 nM). It induces G1 phase arrest and apoptosis, inhibiting proliferation in Jurkat cells (IC50=0.18 µM), and is a valuable tool for cancer research in vitro.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3025082-14-5
• MW: 789.88
• Formula: C₄₁H₄₇N₁₁O₆
• SMILES: O=C1C=NC=2C=NC(=NC2N1C3CCCC3)NC4=CC=C(C=C4)N5CCN(CC5)CCCCC(=O)NCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
• Target: Apoptosis,CDK,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172419466