ZnPc-O3-JQ1

SKU: orb3135661

Description

ZnPc-O3-JQ1 is a light-activated BRD4 degrader. Under light exposure, ZnPc-O3-JQ1 generates reactive oxygen species (ROS), leading to the degradation of BRD4. This degradation results in the downregulation of HIF-1α, effectively countering the tumor hypoxia-induced resistance to photodynamic therapy (PDT). ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 includes three components: a BRD4 ligand, a linker, and a photosensitizer.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research

Images & Validation

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Key Properties

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Target	Epigenetic Reader Domain,HIF/HIF Prolyl-Hydroxylase,ROS

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Epigenetic Reader Domain,HIF/HIF Prolyl-Hydroxylase,ROS

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ZnPc-O3-JQ1

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