Xylometazoline hydrochloride

SKU: orb1310993

Description

Xylometazoline HCl is a selective α1-adrenergic receptor agonist primarily employed as a nasal decongestant. It is widely used in pharmacological research to study vasoconstriction in both in vitro cellular assays and in vivo animal models of nasal congestion.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1218-35-5
• MW: 280.84
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₂₄N₂·HCl
• SMILES: Cl.Cc1cc(cc(C)c1CC1=NCCN1)C(C)(C)C
• Target: Adrenergic Receptor
• Solubility: DMSO:16 mg/mL (56.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.12 mM);Ethanol:52 mg/mL (185.16 mM);H2O:51 mg/mL (181.6 mM)

Bioactivity

• Target IC50:
  α2B-adrenoceptor:1.7 μM (Ki)|α1B-adrenoceptor:560 nM|α2C-adrenoceptor:220 nM|α1A-adrenoceptor:80 nM|α1D-adrenoceptor:450 nM|α2A-adrenoceptor:980 nM
• In Vitro:
  Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22 μM, repectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α2C-adrenergic receptor, α1A-adrenergic receptor, α1B-adrenergic receptor, α1D-adrenergic receptor, α2B-adrenergic receptor, α2A-adrenergic receptor, runny nose, Xylometazoline, Xylometazoline HCl, Xylometazoline hydrochloride, Xylometazoline Hydrochloride, Inhibitor, increase nasal airflow, inhibit, nose stuffiness, AdrenergicReceptor, Adrenergic Receptor, constrict nasal blood vessels, Beta Receptor

Compound Identifiers

PubChem CID

5282386