Xanthohumol

SKU: orb1304306

Description

Xanthohumol is a prenylated chalcone with chemopreventive properties, acting as a COX-1 and COX-2 inhibitor. It is widely used in research areas such as cancer chemoprevention, inflammation, and metabolic studies, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Key Properties

• CAS Number: 6754-58-1
• MW: 354.41
• Purity: >98%
• Formula: C₂₁H₂₂O₅
• SMILES: COc1cc(O)c(C\C=C(/C)C)c(O)c1C(=O)\C=C\c1ccc(O)cc1
• Target: ATPase
• Solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).

Bioactivity

• Target IC50:
  DGAT-1:40 μM (IC50)|DGAT-2:40 μM (IC50)
• In Vivo:
  In CETP-Tg mice, xanthohumol (p.o.) prevents cholesterol accumulation leading to atherosclerosis. In TRAMP mice, xanthohumol (p.o.) induces a decrease in the average weight of the urogenital (UG) tract, delays advanced tumor progression and inhibits the growth of poorly differentiated prostate carcinoma.
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• In Vitro:
  Xanthohumol inhibits Cyp1A activity and induces QR activity in mouse hepatoma cell culture. Xanthohumol scavenges reactive oxygen species and inhibits superoxide anion radical and nitric oxide production. In addition, Xanthohumol prevents carcinogenesis via inhibition of DNA synthesis and induction of cell cycle arrest in S phase, apoptosis, and cell differentiation. Xanthohumol shows potent anti-HIV-1 activity.
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• Cell Research:
  HL-60 cells are maintained in RPMI 1640 supplemented with 10% FBS at 37°C in a 5% CO2 atmosphere. Log-phase cells with a population doubling time of 14–16 h are used for experiments. Serial 2-fold dilutions of compounds (dissolved in DMSO, final concentration 0.1%) in a final concentration range of 0.2–12.5 μM are prepared in 24-well plates using 1 ml of RPMI/well. Control wells obtain the same amount of solvent. Subsequently, 1 ml of the cell suspension is added to the wells. After 96 h, the experiment is evaluated. Cell numbers are counted using a Casy 1 TTC flow-cytometer. The proliferation of treated cells is expressed as a percentage in comparison with the solvent control.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Xanthohumol, Influenza Virus, InfluenzaVirus, mono- acylglycerol acyltransferase, inhibit, HSV, Inhibitor, Herpes simplex virus, acyl-CoA:cholesterol acyltransferase, Acyltransferase, Apoptosis, Diacylglycerol acyltransferase, Diglyceride acyltransferase, Cyclooxygenase, Cytomegalovirus, COX, CMV

Compound Identifiers

PubChem CID

639665