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Vonafexor

SKU: orb1220251

Description

Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.(In Vitro):Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).

Images & Validation

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Key Properties

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CAS Number1192171-69-9
MW489.76
Purity>98% (HPLC)
FormulaC??H??Cl?N?O?S
SMILESO=C(C1=CC2=C(Cl)C(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=CC=C2O1)O
TargetFXR
SolubilityDMSO : 83.33 mg/mL (170.14 mM; Need ultrasonic)

Bioactivity

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In Vitro
Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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EYP001

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  • Vonafexor [orb1298906]

    >99.99% (May vary between batches)

    1192171-69-9

    489.76

    C19H15Cl3N2O5S

    10 mg, 25 mg, 100 mg, 1 ml x 10 mM (in DMSO), 50 mg
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Protocol Information

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200 mg
500 mg
5 mg
$ 120.00
10 mg
$ 190.00
25 mg
$ 340.00
50 mg
$ 580.00
100 mg
$ 860.00