UNC2881

SKU: orb1305245

Description

UNC2881 is a potent and selective small molecule inhibitor of Mer tyrosine kinase (MERTK), exhibiting an IC50 of 4.3 nM with 83-fold and 58-fold selectivity over Axl and Tyro3, respectively. This inhibitor is a valuable research tool for studying MERTK signaling in oncology and immunology, applicable in both in vitro cellular assays and in vivo model systems.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 1493764-08-1
• MW: 463.58
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₃₃N₇O₂
• SMILES: CCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(NC2CCC(O)CC2)n1
• Target: Influenza Virus,TAM Receptor,AXL
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.12 mM);DMSO:85 mg/mL (183.36 mM);Ethanol:5 mg/mL (10.79 mM)

Bioactivity

• Target IC50:
  Mer:4.3 nM
• In Vivo:
  UNC2881 inhibits the activity of Mer kinase in 697 B-ALL cells (IC50: 22 nM) and suppresses collagen-stimulated platelet aggregation.
• In Vitro:
  In mice, UNC2881 exhibits a high total clearance rate (94.5 ml/kg/min), with an oral bioavailability of 14%.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Axl, AXL, Mer, Inhibitor, inhibit, pathologic thrombosis, orally active, platelet aggregation, TAM Receptor, TAMReceptor, phosphorylation, Tyro3, UNC2881, UNC-2881, UNC 2881

Compound Identifiers

PubChem CID

71721525