Tween 80

SKU: orb2279274

Description

Tween 80 is a nonionic surfactant commonly employed in pharmacological research to improve compound solubility in aqueous solutions. Its properties also make it useful for reducing bacterial adhesion and biofilm formation in both in vitro and in vivo experimental models.

Key Properties

• CAS Number: 9005-65-6
• MW: 604.822
• Purity: 98.00% (May vary between batches)
• Formula: C₃₂H₆₀O₁₀
• SMILES: CCCCCCCC\C=C/CCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO
• Target: Others

Bioactivity

• Target IC50:
  ACh (100 μM)-induced inwaRD cells currents:610 nM|HLMs:1.447 mg/mL
• In Vivo:
  METHODS: To study the effect of solvents on locomotor activity in mice, Tween-80/Tween-20 (4%-64% (v/v) in saline) was administered intraperitoneally as a single injection to (BALB/c * DBA/2) F1 mice, and the locomotor activity was monitored for 12 h after the administration. RESULTS: Tween-80 significantly decreased the locomotor activity of mice at a concentration of 32%, while Tween-20 significantly decreased the locomotor activity of mice at a concentration of 16%. METHODS: To detect anti-tumor activity in vivo, ATL (15-30 mg/kg in 5% DMSO + 30% PEG300 + 10% Tween 80 + 55% PBS) was injected intraperitoneally into BALB/c mice harboring human thyroid carcinoma tumor 8505C once daily for nine weeks. RESULTS: ATL inhibited the growth of 8505C cell xenografts in vivo.
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• In Vitro:
  METHODS: S. aureus, L. monocytogenes, and P. fluorescens were treated with Tween 80 (0.1% (v/v) in TSB), and growth curves were documented by measuring optical densities at OD600 every 20 min. RESULTS: Tween 80 increased the growth rate of S. aureus. tween 80 did not affect the growth of L. monocytogenes. the growth rate of the P. fluorescens tween 80 group was initially higher than that of the control group, but then declined again, with the maximum OD significantly lower than that of the control.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Polysorbate80, Polysorbate-80, Polysorbate 80, Tween 80, Tween80, Tween-80, Inhibitor, inhibit

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Gene Symbol

Others