Tulathromycin A

SKU: orb1303006

Description

Tulathromycin A (CP 472295) is a semisynthetic macrolide antibiotic used in research for studying antibacterial mechanisms. It is applied in both in vitro susceptibility assays and in vivo models of respiratory infections in livestock species.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 217500-96-4
• MW: 806.08
• Purity: 99.93% (May vary between batches)
• Formula: C₄₁H₇₉N₃O₁₂
• SMILES: [H][C@@]1(C[C@@](C)(OC)[C@](O)(CNCCC)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:60 mg/mL (74.43 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.48 mM)

Bioactivity

• Target IC50:
  Antibacterial:1 microg/ml (MIC90 for Pasteurella multocida)
• In Vivo:
  Each study randomly allocated 250 calves to receive tulathromycin at 2.5 mg/kg and 250 calves to receive either florfenicol at 40 mg/kg or tilmicosin at 10 mg/kg on arrival at the feedlot. Calves were housed by treatment group in pens with 50 calves/pen. The treatment groups were physiologic saline (n=160) given SC at 0.02 ml/kg, tulathromycin (n=20) given SC at 2.5 mg/kg, and tilmicosin (n = 320) given SC at 10 mg/kg.
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• In Vitro:
  145 calves were inoculated by two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 μg/ml). Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures, and lung lesion scores were significantly lower for tulathromycin-treated calves (P < .01). Tulathromycin was highly effective in the treatment of BRD due to M. bovis in calves regardless of the minimum inhibitory concentration of the challenge strain (1 or >64 μg/ml). The MIC90 for tulathromycin were 1 μg/ml for Pasteurella multocida (bovine), 2 μg/ml for Mannheimia (Pasteurella) haemolytica, and 2 μg/ml for Pasteurella multocida (porcine) and ranged from 4-16 μg/ml for Actinobacillus pleuropneumoniae and from 0.5-4 μg/ml for Histophilus somni (Haemophilus somnus).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cattle, Draxxin, CP472295, CP-472295, CP 472295, Bacterial, Antibacterial, Antibiotic, Inhibitor, leukocytes, inhibit, pneumonia, ribosome, swine, Tulathromycin, Tulathromycin A

Compound Identifiers

PubChem CID

9832301