TRIM

SKU: orb1306819

Description

TRIM (1-(2-Trifluoromethylphenyl)imidazole) is a selective neuronal nitric oxide synthase (nNOS) inhibitor. It is a valuable research tool for investigating the role of nNOS in neurological functions and disorders, applicable in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 25371-96-4
• MW: 212.18
• Purity: >98%
• Formula: C₁₀H₇F₃N₂
• SMILES: FC(F)(F)C1=C(C=CC=C1)N1C=CN=C1
• Target: NOS (Nitric oxide synthase)
• Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).

Bioactivity

• In Vivo:
  TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM. TRIM (10-50 mg kg-1) administered i.p. exhibits dose-related antinociceptive activity in the mouse (assessed as inhibition of late phase formalin-induced hindpaw licking behaviour) with an ED50 of 85.8 mumol kg-1. In contrast, TRIM (50 mg kg-1, i.p.) failed to influence mean arterial blood pressure in the urethane-anaesthetized mouse.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anxiolytic-like effects, antidepressant, 1-(2-Trifluoromethylphenyl)imidazole, inhibit, NOS, Nitric oxide synthases, NO Synthase, nNOS, eNOS, iNOS, Inhibitor, TRIM

Compound Identifiers

PubChem CID

1359