Torsemide

SKU: orb1308696

Description

Torsemide (AC-4464) is a loop diuretic of the anilinopyridine sulfonylurea class, characterized by its extended plasma half-life, prolonged action, and high protein binding. It is widely used in research models of hypertension, heart failure, and edema to investigate renal sodium-potassium-chloride cotransporter inhibition in both in vivo and in vitro systems.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 56211-40-6
• MW: 348.42
• Purity: 99.84% (May vary between batches)
• Formula: C₁₆H₂₀N₄O₃S
• SMILES: CC(C)NC(=O)NS(=O)(=O)C1=C(NC2=CC=CC(C)=C2)C=CN=C1
• Target: Na-K-Cl cotransporter,Others
• Solubility: DMSO:22.5 mg/mL (64.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.87 mM)

Bioactivity

• In Vivo:
  The primary action site of Torsemide is the thick ascending limb of the loop of Henle, where it promotes the excretion of water, sodium, and chloride by interacting with the K+, Na+, Cl- transporter. Torsemide disrupts the binding and secretion of aldosterone in a dose-dependent manner. It inhibits aldosterone secretion, which is produced by adrenal cortical cells of mice, guinea pigs, and cattle, and is stimulated in vivo by angiotensin, adrenocorticotropic hormone, butyryl cyclic AMP, corticosterone, or in vitro.
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• In Vitro:
  In rats, compared to baseline levels, Torsemide increases blood urea nitrogen (BUN) and plasma creatinine concentrations, and significantly and rapidly augments urine output. In canines with mitral valve closure, Torsemide elevates circulating angiotensin II and aldosterone levels, whereas furosemide only increases the level of angiotensin II.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC 4464, AC4464, AC-4464, anti-aldosterone, diuretic, disease, cirrhosis, failure, hepatic, heart, JDL 464, JDL464, JDL-464, inhibit, Inhibitor, NaKCl cotransporter, Na-K-Cl cotransporter, NaKClcotransporter, vasodilatory, Torsemide, Torasemide, renal

Compound Identifiers

PubChem CID

41781