Tolmetin sodium dihydrate

SKU: orb1909154

Description

Tolmetin sodium dihydrate is an orally active NSAID and COX inhibitor, with IC₅₀ values of 0.35 µM (COX-1) and 0.82 µM (COX-2). It serves as a key reference compound for investigating NSAID mechanisms and is widely used in both in vitro enzymatic assays and in vivo models of inflammation and pain.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64490-92-2
• MW: 315.3
• Purity: 99.57% (May vary between batches)
• Formula: C₁₅H₁₈NNaO₅
• SMILES: O=C(CC1=CC=C(N1C)C(C2=CC=C(C)C=C2)=O)[O-].[Na+].O.O
• Target: COX
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (3.17 mM);DMSO:10 mg/mL (31.72 mM);H2O:≥ 80 mg/mL

Bioactivity

• Target IC50:
  COX-1 (human):0.35 μM|COX-2 (human):0.82 μM
• In Vivo:
  In male Wistar rats, the ulcerogenic effect of Tolmetin sodium dihydrate (30, 100 mg/kg, oral administration) reached its peak 4 hours after a single dose, while this effect significantly weakened after repeated administration for 3 and 14 days . Pretreatment with Tolmetin sodium dihydrate (5 mg/kg, twice daily) for 5 consecutive days effectively alleviated quinolinic acid (QA)-induced neurotoxicity .
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• In Vitro:
  Tolmetin sodium dihydrate (0.25 mM) showed no inhibitory effect on lipid peroxidation in rat brain homogenates . Tolmetin sodium dihydrate (0.001-100 μM) exhibited dose-dependent anticancer activity against HT-29 colon carcinoma cells . Tolmetin sodium dihydrate (0-100 μM) had no significant effect on osteoblast growth .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tolmetin (sodium salt hydrate)

Compound Identifiers

PubChem CID

23677829