TC-S 7003

SKU: orb1707088

Description

TC-S 7003 is a potent, orally bioavailable inhibitor of lymphocyte-specific kinase (Lck), also showing activity against Lyn, Src, and Syk. It suppresses T-cell proliferation and exhibits anti-inflammatory effects, making it a useful research tool for studying autoimmune conditions like arthritis in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 847950-09-8
• MW: 530.62
• Purity: 99.74% (May vary between batches)
• Formula: C₃₁H₃₀N₈O
• SMILES: O=C1C2=CN=C(N=C2N3C(=NC=4C=CC=CC43)N1C=5C(=CC=CC5C)C)NC6=CC=C(C=C6)N7CCN(C)CC7
• Target: Syk,Src
• Solubility: DMSO:80 mg/mL (150.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.22 mM)

Bioactivity

• Target IC50:
  IL-2:0.46 μM|T cells:0.53 μM
• In Vivo:
  A once-daily dose of TC-S 7003 was administered orally at 10, 30, and 60 mg/kg from day 9 to day 17. TC-S 7003 showed a dose-dependent inhibition of arthritis (ED50=24 mg/kg).
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• In Vitro:
  TC-S 7003 exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (IL- 2) and also inhibited subsequent T-cell proliferation (T-cell prolif.) in the same human T -cells, IL-2, IC50=0.46 μM, T-cell prolif, IC50=0.53 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lyn, Lck, Lck Inhibitor, Syk, Src

Compound Identifiers

PubChem CID

11785878