Tasosartan

SKU: orb1299497

Description

Tasosartan (WAY-ANA 756) is a potent and selective angiotensin II type 2 (AT2) receptor antagonist with an IC50 of 1.2 nM. This small molecule is a valuable research tool for investigating the AT2 receptor's role in cardiovascular and renal function in both in vitro and in vivo studies.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 145733-36-4
• MW: 411.46
• Purity: 99.48% (May vary between batches)
• Formula: C₂₃H₂₁N₇O
• SMILES: Cc1nc(C)c2CCC(=O)N(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2n1
• Target: RAAS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.72 mM);DMSO:125 mg/mL (303.8 mM)

Bioactivity

• Target IC50:
  Ang II type 2 receptor:1.2 nM
• In Vivo:
  In vivo, tasosartan (p.o. or i.v.) blocked by 80% AT1 receptors 1 to 2 h after drug administration and still had a 40% effect at 32 h.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Angiotensin Receptor, AT2 receptor, WAY-ANA 756, WAY-ANA-756, WAY-ANA756, Tasosartan

Compound Identifiers

PubChem CID

60919