Sulpiride

SKU: orb1226092

Description

Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class, used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 15676-16-1
• MW: 341.43
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₃N₃O₄S
• SMILES: O=C(NCC1N(CC)CCC1)C2=CC(S(=O)(N)=O)=CC=C2OC
• Target: Dopamine Receptor
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Animal model: Sprague-Dawley rats model. Dosage: 50 mg/kg. Administration: Subcutaneous injection (s. c.); Single dose. Result: Caused dopamine concentrations in the dialysates to roughly double. Animal model: 6-hydroxydopamine (6-OHDA) male NMRI mouse model of Parkinson’s disease (PD). Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg. Administration: Intraperitoneal injection (i.p.); Single dose. Result: Decreased %OAT (open-arm time) but had no significant effect on %OAE (open-arm entries) and locomotor activity. Animal model: Female nu/nu nude mouse models of breast cancer bearing MCF-7/Adr xenografts. Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg. Administration: Oral gavage (p.o.); Once daily for 18 days. In combination with DEX (1 and 10 mg/kg; p.o. ; Once daily for 18 days). Result: When used in combination with DEX (1 mg/kg) at 50 m/kg, enhanced the tumor suppression rate (14.4%). When combined with DEX (8 mg/kg) at 25, 50, and 100 mg/kg, enhanced the tumor suppression rate by 30.2%, 27.55%, and 14.97%, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

rac-Sulpiride | RD 1403 | (RS)-(±)-Sulpiride | (S)-Sulpiride

Quick Database Links

Gene Symbol

Dopamine Receptor