Succinic acid

SKU: orb1305118

Description

Succinic acid is a key metabolic intermediate, functioning both in the anaerobic metabolic pathways and as a central component of the aerobic tricarboxylic acid (TCA) cycle. It is widely utilized in research applications involving cellular metabolism, mitochondrial function, and energy production studies in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 110-15-6
• MW: 118.09
• Purity: 99.88% (May vary between batches)
• Formula: C₄H₆O₄
• SMILES: OC(=O)CCC(O)=O
• Target: Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (42.34 mM);DMSO:255 mg/mL (2159.37 mM);H2O:5.9 mg/mL (49.96 mM)

Bioactivity

• Target IC50:
  CYP3A4:12.82 μM|CYP2D6:14.53 μM|CYP2C9:19.60 μM
• In Vivo:
  METHODS: To study the anti-anxiety effect of Succinic acid, a single dose of Succinic acid (3.0 and 6.0 mg/kg) was orally administered by gavage to the mouse model of the elevated plus maze test. Single-dose Succinic acid (3, 6, 12 mg/kg) was intraperitoneally injected into the mouse model of the elevated plus maze test. Single-dose Succinic acid (1.5, 3, 6 mg/kg) was orally administered by gavage to the mouse model of stress-induced hyperthermia. RESULTS: Succinic acid significantly increased the percentage of mice entering the open arm and the percentage of time they stayed in the open arm. Succinic acid significantly increased the food intake of mice within 5 minutes after administration. Succinic acid inhibited stress-induced hyperthermia at a dose of 1.5 mg/kg.
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• In Vitro:
  METHODS: After treating HEK-293 JumpIN-SLC13A3 cells with Succinic acid, the substrate uptake of Na(+)/ dicarboxylic acid cotransporter 3 (NADC3, SLC13A3) was evaluated using fluorescent FLIPR membrane potential dye. RESULTS: The EC50 of Succinic acid on HEK-293 cells was 107 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

orally active, inhibit, EndogenousMetabolite, fermentation, Inhibitor, Endogenous Metabolite, 1,2-Ethanedicarboxylic acid, 1,4-Butandioic Acid, anaerobic, Amber acid, anxiolytic, Asuccin, Butanedioic acid, Succinic acid, Wormwood acid, precursor

Compound Identifiers

PubChem CID

1110