S-23

SKU: orb1306534

Description

S-23 is a potent oral SARM with a 1.7 nM Ki for the androgen receptor. It demonstrates tissue-selective anabolic activity, evidenced by its ability to increase weights of the levator ani muscle, prostate, and seminal vesicles in castrated rat models, supporting its use in androgen receptor research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1010396-29-8
• MW: 416.75
• Purity: 99.55% (May vary between batches)
• Formula: C₁₈H₁₃ClF₄N₂O₃
• SMILES: C[C@](O)(COc1ccc(Cl)c(F)c1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F
• Target: Androgen Receptor
• Solubility: DMSO:50 mg/mL (119.98 mM)

Bioactivity

• Target IC50:
  Androgen receptor:1.7 nM(Ki)
• In Vivo:
  Administration of S-23 to castrated animals increases the weights of the androgen-dependent organ dose-dependently with the ED50s of S-23 in the prostate and levator ani muscle of 0.43 and 0.079 mg/d, respectively.
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• In Vitro:
  Administration of 10 nM S-23 induces AR-mediated transcriptional activation in CV-1 cells .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

levator, Inhibitor, inhibit, muscle, cells, CV-1, castrated, Androgen Receptor, AndrogenReceptor, ani, (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide, activation, vesicle, transcriptional, S 23, S23, S-23, prostate, seminal

Compound Identifiers

PubChem CID

24892822