Rutin

SKU: orb1310285

Description

Rutin (Quercetin 3-O-rutinoside) is a BBB-permeable flavonoid with diverse bioactivities. It is widely used in research for its neuroprotective, antioxidant, and anti-inflammatory properties, applicable in both in vitro assays and in vivo models for studying metabolic and age-related disorders.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 153-18-4
• MW: 610.52
• Purity: 97.19% (May vary between batches)
• Formula: C₂₇H₃₀O₁₆
• SMILES: O(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2)C3=CC(O)=C(O)C=C3)[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@H]4O
• Target: Prostaglandin Receptor,Endogenous Metabolite,Beta Amyloid,Apoptosis,Autophagy
• Solubility: DMSO:235 mg/mL (384.92 mM);Ethanol:2 mg/mL (3.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:12.2 mg/mL (19.98 mM)

Bioactivity

• Target IC50:
  Xanthine Oxidase (XOD):60.811 ± 0.19 μmol/L|LN-229 cells:22 ± 4.8 µM|SK-N-SH cells:36 ± 3.7 µM|BChE:18.15 μg/mL|OATP2B1:2.32 μM (EC50)|HCT116 cells:31.25 μg/mL|A549 cells:> 10 μM|Neuro-2a cells:24 ± 4.3 µM|SH-SY5Y cells:> 40 µM
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• In Vivo:
  Rutin inhibits platelet aggregation and diminishes capillary permeability, thinning the blood and enhancing circulation. Consequently, Rutin may prevent blood clot formation and is utilized in treating heart disease and stroke.
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• In Vitro:
  The intraperitoneal injection in mice has determined the median lethal dose (LD50) of Rutin to be 650 mg/kg.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Amyloid, BetaAmyloid, AKR, Abeta, Autophagy, b Amyloid, antidiabetic, antioxidant, anti-inflammatory, Amyloid-β, brain, bAmyloid, barrier, blood, nephroprotective, neuroprotective, inhibit, flavonoid, Inhibitor, hepatoprotective, Rutin, Rutoside, Prostaglandin Receptor, ProstaglandinReceptor, Quercetin 3-O-rutinoside, β-amyloid peptide, β Amyloid, βAmyloid

Compound Identifiers

PubChem CID

5280805