Rutaevin

SKU: orb1297214

Description

Rutaevin is a potential anti-inflammatory agent that inhibits nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. This in vitro activity supports its research use in studying inflammatory pathways and macrophage biology.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 33237-37-5
• MW: 486.51
• Purity: 99.99% (May vary between batches)
• Formula: C₂₆H₃₀O₉
• SMILES: C[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]67[C@](C(=O)[C@@H]2O)(C(C)(C)O[C@]6(CC(=O)OC7)[H])[H])[H]
• Target: Reactive Oxygen Species,ROS,NO Synthase
• Solubility: DMSO:60 mg/mL (123.33 mM)

Bioactivity

• In Vitro:
  A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α±-hydroxyRutaevin (7), and Rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NOSynthase, Inhibitor, NO Synthase, macrophage, Euodia rutaecarpa, production, Reactive Oxygen Species, ReactiveOxygenSpecies, RAW 264.7, Rutaevin

Compound Identifiers

PubChem CID

9848259