RSV-IN-1

SKU: orb1309146

Description

RSV-IN-1 is a potent small-molecule inhibitor of human respiratory syncytial virus (hRSV), demonstrating antiviral activity with an IC50 of 0.11 μM. It is a valuable research tool for studying RSV replication and has been utilized in both in vitro antiviral assays and in vivo animal models of RSV infection.

Research Area

Infectious Disease & Virology, Infectious Disease & Virology; Musculoskeletal & Connective Tissue Research

Key Properties

• CAS Number: 861139-16-4
• MW: 427.477
• Purity: 99.36% (May vary between batches)
• Formula: C₂₀H₂₁N₅O₄S
• SMILES: COC1=C(C=C(C=C1)S(=O)(=O)N(C)CCO)C1=NN=C2N1N=C(C)C1=C2C=CC=C1
• Target: RSV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.36 mM);DMSO:125 mg/mL (292.41 mM)

Bioactivity

• Target IC50:
  RSV (human):0.11μM
• In Vitro:
  The concentration of P13 that reduces the number of RSV plaques (IC50 is 0.11 μM, in HEp-2 cells), with a CC50 of 310 μM for reducing HEp-2 cell viability, results in a selective index (CC50/IC50) of 2818. These escape plaques are smaller and exhibit a non-syncytial phenotype compared to plaques formed without the inhibitor.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Respiratory syncytial virus, RSV IN 1, RSVIN1, RSV-IN-1, RSV, hRSV, inhibit, Inhibitor

Compound Identifiers

PubChem CID

3943763