Ro 25-6981 Maleate

SKU: orb1708648

Description

Ro 25-6981 Maleate is a potent and selective antagonist of the NMDA receptor's NR2B subunit. It exhibits anticonvulsant and antidepressant properties, making it a valuable pharmacological tool for in vitro and in vivo research on neurological conditions including Parkinson's disease, epilepsy, and neuropathic pain.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1312991-76-6
• MW: 455.54
• Purity: 99.85% (May vary between batches)
• Formula: C₂₆H₃₃NO₆
• SMILES: OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1
• Target: NMDAR,iGluR
• Solubility: H2O:4 mg/mL (8.78 mM);DMSO:61 mg/mL (133.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.98 mM)

Bioactivity

• In Vivo:
  In 6-OHDA-lesioned rats, Ro 25-6981 Maleate (0.39-12.5 mg/kg; intraperitoneal injection) dose-dependently induces contralateral tight nose-to-tail rotations and elicits a weak ipsilateral circling response, indicating a mild nonspecific stimulatory action of the compound.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NMDA receptor, Ro-25-6981 Maleate, Ro 25 6981 Maleate, Ro 256981 Maleate, Ro 25-6981 Maleate

Compound Identifiers

PubChem CID

53250677