(R)-KMH-233

SKU: orb3143345

Description

(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2994330-89-9
• MW: 587.58
• Formula: C₃₂H₂₅N₇O₅
• SMILES: N(C(=O)C1=CC(C[C@H](C(O)=O)N)=CC=C1)C=2N3C(C(C#N)=C(C2C#N)C4=CC=C(OCC(NC)=O)C=C4)=NC=5C3=CC=CC5
• Target: ASCT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ASCT