Quinidine

SKU: orb1299368

Description

Quinidine is a stereoisomer of quinine and functions as a class Ia antiarrhythmic agent. It is utilized in research on cardiac arrhythmias and malaria, serving as a pharmacological tool for both in vitro electrophysiology studies and in vivo animal models of disease.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 56-54-2
• MW: 324.4168
• Purity: 99.99% (May vary between batches)
• Formula: C₂₀H₂₄N₂O₂
• SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@H](O)[C@H]1C[C@@H]2CCN1C[C@@H]2C=C
• Target: Cytochromes P450,Parasite,Potassium Channel,Apoptosis
• Solubility: DMSO:50 mg/mL (154.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.16 mM)

Bioactivity

• In Vitro:
  Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Quinidine, Potassium Channel, Apoptosis, CYPs, Cytochrome P450, KcsA, inhibit, Inhibitor, Parasite, MES-SA, MESSA/DX5, oral activity, malaria

Compound Identifiers

PubChem CID

441074