Quercetin 3-gentiobioside

SKU: orb1684285

Description

Quercetin 3-gentiobioside

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 7431-83-6
• MW: 626.52
• Purity: 99.94% (May vary between batches)
• Formula: C₂₇H₃₀O₁₇
• SMILES: OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(oc4cc(O)cc(O)c4c3=O)-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Reductase,Cytochromes P450
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.27 mM);DMSO:90 mg/mL (143.65 mM)

Bioactivity

• Target IC50:
  AGE:109.46±1.41|AR:10.6±0.38
• In Vivo:
  Treatment with quercetin 3-O-gentiobioside (HF diet-induced obese mice; 0.1% Iso and Que) reduced blood glucose and serum insulin levels and improved glucose tolerance in obese mice. Meanwhile, serum triglyceride levels and liver morphology in the mice were significantly ameliorated by EO and isoquercitrin treatment. Total cholesterol levels in quercetin 3-O-gentiobioside treated mice were also reduced.
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• In Vitro:
  We led to isolation of Quercetin-3-gentiobioside was first reported on the isolation from A. iwayomogi. A. iwayomogi extracts showed significant inhibitor on AR and AGEs formation activities We also determined quercetin 3-O-gentiobioside have antioxidant activity in vitro.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Quercetin-3-gentiobioside, Quercetin 3-gentiobioside, Aldose reductase, AGE

Compound Identifiers

PubChem CID

5320834