Pyronaridine tetraphosphate

SKU: orb1706751

Description

Pyronaridine tetraphosphate is an orally active mannitol adduct that inhibits DNA topoisomerase II and exhibits antimalarial, antitumor, and anti-echinococcal activity. Research applications include in vitro studies against Plasmodium falciparum and in vivo models for investigating its potential to attenuate viral infections such as Ebola.

Research Area

Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 76748-86-2
• MW: 910.03
• Purity: 99.82% (May vary between batches)
• Formula: C₂₉H₄₄ClN₅O₁₈P₄
• SMILES: OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.COC1=NC2=C(NC3=CC(CN4CCCC4)=C(O)C(CN4CCCC4)=C3)C3=CC=C(Cl)C=C3N=C2C=C1
• Target: Parasite,Topoisomerase
• Solubility: DMSO:10 mg/mL (10.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.1 mM);H2O:20 mg/mL (21.98 mM)

Bioactivity

• Target IC50:
  P. falciparum:1.53-3.94 nM
• In Vivo:
  Reducing the parasitic burden in Echinococcus granulosus-infected mice, pyronaridine tetraphosphate (57 mg/kg, oral administration, q.d. for 30 days) has been demonstrated.Reducing the parasitic burden in secondarily infected (cysts) mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, q.d. for 3 days) has shown efficacy.Exhibiting a higher exposure in the liver than in the plasma in male ICR mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, for a single dose) has been observed.
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• In Vitro:
  With an IC50 value of 1.53-3.94 nM, pyronaridine tetraphosphate (24 h) exhibits anti-P. falciparum activity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pyronaridine, Pyronaridine tetraphosphate, topoisomerase II

Compound Identifiers

PubChem CID

156867