Procainamide

SKU: orb1689694

Description

Procainamide is a Class 1A antiarrhythmic agent and a specific DNMT1 inhibitor. Its dual mechanism supports research in cardiac arrhythmias and epigenetic cancer studies, with applications in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51-06-9
• MW: 235.3253
• Purity: 99.92% (May vary between batches)
• Formula: C₁₃H₂₁N₃O
• SMILES: CCN(CC)CCNC(=O)C1=CC=C(N)C=C1
• Target: Potassium Channel,DNA Methyltransferase
• Solubility: DMSO:45 mg/mL (191.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.25 mM)

Bioactivity

• In Vitro:
  HCT116, HCT116 DNMT1−/−, and HCT116 DNMT3b−/− cells were treated with PBS, pH 7.4 or 0.5 mM procainamide for 96 h. Procainamide treatment of HCT116 DNMT3b−/− cells decreased m5dC content by 11.5%, but treatment of HCT116 DNMT1−/− cells did not decrease m5dC content. These results suggested that DNMT1 was the intracellular target of procainamide.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Methyltransferase, DNAMethyltransferase, DNMT1, Biocoryl, Novocainamide, Procainamide

Compound Identifiers

PubChem CID

4913