Pregnenolone

SKU: orb1310235

Description

Pregnenolone

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 145-13-1
• MW: 316.4776
• Purity: >99.99% (May vary between batches)
• Formula: C₂₁H₃₂O₂
• SMILES: CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C
• Target: Endogenous Metabolite,TRP/TRPV Channel,Cannabinoid Receptor,AChR,Autophagy
• Solubility: Ethanol:21 mg/mL (66.35 mM);DMSO:3.33 mg/mL (10.52 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors.
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• In Vitro:
  Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, 3β-Hydroxy-5-pregnen-20-one, 3b-Hydroxy-5-pregnen-20-one, 3beta-Hydroxy-5-pregnen-20-one, CB, CannabinoidReceptor, Cannabinoid Receptor, Autophagy, Arthenolone, Inhibitor, Endogenous Metabolite, inhibit, mAChR, Pregnenolone, Transient receptor potential channels, TRPChannel, TRP Channel, TRPVChannel, TRPV Channel

Compound Identifiers

PubChem CID

8955