Prednisolone valerate acetate

SKU: orb1705452

Description

Prednisolone valerate acetate

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 72064-79-0
• MW: 486.6
• Purity: 99.93% (May vary between batches)
• Formula: C₂₈H₃₈O₇
• SMILES: C(COC(C)=O)(=O)[C@]1(OC(CCCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]
• Target: Glucocorticoid Receptor
• Solubility: DMSO:4 mg/mL (8.22 mM)

Bioactivity

• In Vivo:
  Prednisolone valerate acetate (PVA) was administered to mice via s.c. injection at 0.03–1 mg/kg, with immune responses assessed at 24–48 h and 5–7 d for antibody production. PVA reduced spleen weight and splenic nucleated cell counts, suppressed hemolytic plaque-forming cell (PFC) formation, delayed-type hypersensitivity (DTH), and ConA-induced splenocyte proliferation. Notably, PVA inhibited LPS-induced splenocyte response and IgM antibody production at lower doses than hydrocortisone 17-butyrate (HB), indicating higher potency. Unlike HB and betamethasone 17-valerate (BV), PVA had no effect on PHA-P response. Its suppression of host defense against experimental E. coli infection was weaker than that of HB and BV.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Acepreval, Lidomex, Prednisolone valerate Acetate

Compound Identifiers

PubChem CID

5284612