PPQ-102

SKU: orb1307285

Description

PPQ-102 is a potent and selective small-molecule CFTR inhibitor, demonstrating complete blockade of the CFTR chloride channel with an IC50 of 90 nM. This tool compound is widely used in vitro to investigate CFTR function in epithelial physiology and is applied in research models of secretory diarrheas and polycystic kidney disease.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 931706-15-9
• MW: 438.4779
• Purity: 99.70% (May vary between batches)
• Formula: C₂₆H₂₂N₄O₃
• SMILES: CN1C2=C3C(NC4=C(C=CC=C4)N3C(=C2C(=O)N(C)C1=O)C1=CC=CC=C1)C1=CC=C(C)O1
• Target: Autophagy,CFTR
• Solubility: DMSO:55 mg/mL (125.43 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.56 mM)

Bioactivity

• Target IC50:
  CFTR:90 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

polycystic kidney disease, PPQ102, PPQ-102, PPQ 102, E13.5 embryonic kidneys, Cystic fibrosis transmembrane conductance regulator, CFTR Inhibitor, CFTR, Autophagy, Inhibitor, inhibit

Compound Identifiers

PubChem CID

16016583