Polyphyllin I

SKU: orb1303595

Description

Polyphyllin D is a bioactive steroidal saponin with potent anticancer activity, inducing mitochondrial-mediated apoptosis and overcoming drug resistance in vitro. Its mechanisms include Bcl-2 downregulation, Bax upregulation, and caspase-3 activation, alongside noted anti-angiogenic and erythrocyte toxicity effects, supporting its research in oncology and hematology studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 50773-41-6
• MW: 855.02
• Purity: 99.50% (May vary between batches)
• Formula: C₄₄H₇₀O₁₆
• SMILES: [H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2)O[C@]1([H])O[C@H](CO)[C@@H](O[C@]2([H])O[C@@H](CO)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
• Target: Akt,mTOR,PDK,JNK,Apoptosis,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.17 mM);DMSO:250 mg/mL (292.39 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mammalian target of Rapamycin, Inhibitor, inhibit, JNK, mTOR, Akt, apoptosis, Apoptosis, Autophagy, Protein kinase B, Polyphyllin I, PDK-1, PDK1, PKB

Compound Identifiers

PubChem CID

11018329