Polaprezinc

SKU: orb1222885

Description

Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Upon administration, polaprezinc increases the expression of various anti-oxidant enzymes, such as superoxide dismutase 1 (SOD-1), SOD-2, heme oxygenase-1 (HO-1), glutathione S-transferase (GST), glutathione peroxidase (GSH-px), peroxidredoxin-1 (PRDX1; PRXI) and PRXD5 (PRXV) in the gastric mucosa, which protect cells against reactive oxygen species (ROS).

Key Properties

• CAS Number: 107667-60-7
• MW: 289.63
• Purity: >98% (HPLC)
• Formula: C₉H₁₂N₄O₃Zn
• SMILES: NCCC(=O)N1[Zn]OC(=O)[C@@H]1Cc1cnc[nH]1
• Target: Others
• Solubility: H2O : 3.37 mg/mL 11.68 mM; DMSO : < 1 mg/mL

Bioactivity

• In Vivo:
  Polaprezinc (PZ) is an antiulcer drug and a chelating compound consisting of a zinc ion, L-carnosine, a β-alanine dipeptide and L-histidine. Polaprezinc exerts antioxidant effects and scavenges free radicals. The efficacy of Polaprezinc is reported for acute radiation proctitis in an Animal model and demonstrates that Polaprezinc has an anti-inflammatory effect following exposure to radiation.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Polaprezinc | Z 103

Quick Database Links

Gene Symbol

Others