PFK15

SKU: orb1305460

Description

PFK-015

Research Area

Cell Biology

Key Properties

• CAS Number: 4382-63-2
• MW: 260.29
• Purity: >98%
• Formula: C₁₇H₁₂N₂O
• SMILES: O=C(\C=C\c1ccc2ccccc2n1)c1ccncc1
• Target: PFKFB3 (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3)
• Solubility: Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)

Bioactivity

• Target IC50:
  PFKFB3:110 nM|PFKFB3:20 nM
• In Vivo:
  PFK-015 effectively reduces levels of F26BP, glucose uptake, and intracellular adenosine triphosphate (ATP) in Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells. Additionally, PFK-015 exhibits significant inhibitory effects on the growth of a variety of cancer cells.
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• In Vitro:
  PFK-015 (25 mg/kg, i.p.) inhibits the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three distinct athymic mouse models of xenografted human cancers, the anticancer efficacy of PFK-015 is comparable to that of established chemotherapy drugs. PFK-015 exhibits favorable pharmacokinetic properties in vivo.
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• Cell Research:
  Viability is determined using trypan blue exclusion. Cells were incubated in 20% trypan blue for 5 minutes. Cells excluding trypan blue are counted using a standard hemocytometer to determine the total number of viable cells. Experiments are conducted in triplicate. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, esophageal squamous cell carcinoma (ESCC), lung cancer, inhibit, 3PO, cancers, Autophagy, colon cancer, stomach cancer, PFKFB3, PFK015, PFK-015, PFK15, PFK-15, PFK 15, PFK 015

Compound Identifiers

PubChem CID

25142799