Pelargonidin chloride

SKU: orb1684975

Description

Pelargonidin chloride is a research compound that protects HepG2 cells from citrinin-induced oxidative damage. It activates the Keap1/Nrf2 pathway, enhancing cellular detoxification enzyme activity. This anthocyanin metabolite is used in studies of hepatoprotection, chemoprevention, and redox signaling in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 134-04-3
• MW: 306.70
• Purity: 99.02% (May vary between batches)
• Formula: C₁₅H₁₁ClO₅
• SMILES: [Cl-].Oc1ccc(cc1)-c1[o+]c2cc(O)cc(O)c2cc1O
• Target: Nrf2,NOS,Reductase,Reactive Oxygen Species,ROS,NO Synthase
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  The effect of PC in ameliorating citrinin (CTN) induced cytotoxicity and oxidative stress. The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 μM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 μM. CTN increased lactate dehydrogenase leakage (59%), elevated reactive oxygen species (2.5-fold), depolarized mitochondrial membrane potential as confirmed by JC-1 monomers and arrested cell cycle at G2/M phase. Further, apoptotic and necrotic analysis revealed significant changes followed by DNA damage. To overcome these toxicological effects, PC was pretreated for 2 h followed by CTN exposure for 24 h. Pretreatment with PC resulted in significant increase in cell viability (84.5%), restored membrane integrity, reactive oxygen species level were maintained and cell cycle phases were normal. PC significantly up-regulated the activity of detoxification enzymes: heme oxygenase 1 (HO-1), glutathione transferase, glutathione peroxidase, superoxide dismutase and quinone reductase. Nrf2 translocation into the nucleus was also observed by immunocytochemistry analysis
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antioxidant, NO Synthase, nitric oxide, NOS, NOSynthase, Inhibitor, Nrf2, inhibit, ReactiveOxygenSpecies, Reactive Oxygen Species, Pelargonidin chloride, Pelargonidin Chloride, Pelargonidin, Radical, scavenger

Compound Identifiers

PubChem CID

67249