Paromomycin Sulfate

SKU: orb1309761

Description

Paromomycin sulfate is an aminoglycoside antibiotic that binds to the 16S rRNA in the bacterial 30S ribosomal A-site, inducing translational misreading and inhibition of protein synthesis. It is widely used in research involving gram-negative bacterial infections, including in vitro antimicrobial studies and in vivo models of amebiasis.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1263-89-4
• MW: 713.71
• Purity: 99.92% (May vary between batches)
• Formula: C₂₃H₄₇N₅O₁₈S
• SMILES: OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
• Target: Parasite,Antibiotic,Antibacterial
• Solubility: H2O:255 mg/mL (357.29 mM);DMSO:Insoluble

Bioactivity

• In Vivo:
  Paromomycin, an aminoglycoside antibiotic, exhibits robust antimicrobial activity against a broad spectrum of Gram-positive bacteria, Gram-negative bacteria, some protozoa, and tapeworms. In vitro analysis of amastigote sensitivity within a mouse macrophage model indicated that L. tropica and the L. major strains (ED50s: 1~5 μM) are more sensitive to Paromomycin than L. mexicana (ED50: 39 μM) and L. braziliensis (ED50: <12 μM). The L. donovani strain demonstrates moderate sensitivity (ED50: 6~18 μM), with the exception of the Indian strain, DD8, exhibiting significantly reduced susceptibility (ED50 >150 μM).
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• In Vitro:
  In both clinical cases and experimental models of cutaneous leishmaniasis (CL), lesions caused by L. major show a faster and more complete recovery when treated with paromomycin ointment as compared to those caused by L. panamensis and L. amazonensis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tapeworm infection, Parasite, parasitic, Paromomycin, Paromomycin Sulfate, Paromomycin sulfate salt, leishmaniasis, giardiasis, Aminosidine, Aminosidine sulfate, amebiasis, Antibiotic, Bacterial, 16S rRNA

Compound Identifiers

PubChem CID

441375