Palonosetron hydrochloride

SKU: orb1226458

Description

Palonosetron (INN, trade name Aloxi) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of its class approved for this use by the U.S. Food and Drug Administration. As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 135729-62-3
• MW: 332.87
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₄N₂O·HCl
• SMILES: C1C[C@@H]2CN(C(=O)C3=C2C(=CC=C3)C1)[C@@H]4CN5CCC4CC5.Cl
• Target: 5-HT Receptor
• Solubility: Water: 67 mg/mL (201.27 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aloxi | RS 25259-197

Quick Database Links

Gene Symbol

5-HT Receptor