P-536

SKU: orb3211483

Description

P-536 is an ACE inhibitor that concurrently inhibits the thymidine kinase of herpes simplex virus (HSV-1) and the RNA polymerase of Trypanosoma cruzi. By suppressing the renin-angiotensin system, downregulating AT1R and NOX4 expression, and decreasing oxidative stress (lowering plasma hydrogen peroxide (H2O2) and 8-isoprostane levels), P-536 effectively reduces systolic blood pressure and enhances vascular reactivity. Additionally, P-536 hinders the replication of DNA/RNA viruses such as HSV-1 by blocking nucleotide metabolism and nucleic acid synthesis; it competitively inhibits Trypanosoma cruzi RNA synthesis, suppresses epimastigote replication, and thereby obstructs their growth. P-536 is applicable in the research of hypertension, insulin resistance, and Chagas disease.

Key Properties

• CAS Number: 93426-60-9
• MW: 945.85
• Formula: C₄₄H₃₉N₃O₁₉S
• SMILES: O(C(=O)C1=CC=CC=C1)[C@@H]2[C@@H](OC(=O)C3=CC=CC=C3)[C@@H](OC(NS(OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)N5C(=O)NC(=O)C=C5)(=O)=O)=O)O[C@H](COC(=O)C6=CC=CC=C6)[C@H]2OC(=O)C7=CC=CC=C7
• Target: Angiotensin-converting Enzyme (ACE),DNA/RNA Synthesis,Parasite,HSV

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Angiotensin-converting Enzyme (ACE),DNA/RNA Synthesis,Parasite,HSV