Oxolinic acid

SKU: orb1309290

Description

Oxolinic acid, a synthetic quinolone antimicrobial related to nalidixic acid, is used to treat urinary tract infections. It serves as a research tool for studying bacterial DNA gyrase inhibition in both in vitro assays and in vivo infection models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 14698-29-4
• MW: 261.2301
• Purity: 99.72% (May vary between batches)
• Formula: C₁₃H₁₁NO₅
• SMILES: CCN1C=C(C(O)=O)C(=O)C2=C1C=C1OCOC1=C2
• Target: DNA/RNA Synthesis,Antibacterial,Antibiotic,Dopamine Receptor
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Dopamine uptake:4.3 μM
• In Vivo:
  The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex.
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• In Vitro:
  Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 μg/ml.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antimicrobial, Antibiotic, Bacterial, bacterial DNA gyrase, Dopamine Receptor, dopamine, dopamine uptake, DopamineReceptor, DNASynthesis, DNA synthesis, DNA Synthesis, DNA/RNA Synthesis, DNA/RNA, Dioxacin, Oxolinic acid, Nidantin, infections, inhibit, NSC110364, NSC-110364, NSC 110364, Emyrenil, Inhibitor, synthesis, tract, RNASynthesis, RNA Synthesis, urinary, Urinox, uptake

Compound Identifiers

PubChem CID

4628